Research - Research Groups - Biophysics Research Group - HAb2 Fibroblast Cell
An HAb2 fibroblast cell (left, lower left, and bottom) with attached bleb (just off center) labeled with the fluorescent lipids lissamine-Rhodamine B-DOPE (red channel) and perylene (blue channel) imaged by laser scanning confocal fluorescence microscopy. The phase-separated cell attached bleb shows two coexisting fluid phases and was induced at room temperature by the addition of a chemical agent. This result is surprising because normally phase separation in cell membranes is not visible to light microscopy due to the extremely small size of domains in unperturbed cell membranes. The image is 36.6 x 36.6 microns in size.
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